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New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients.

Leprosy control is achieved through a fine-tuning of TH1 and TH2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the...

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Bibliographic Details
Main Authors: Pedro Henrique Papotto (Author), Solange Maeda (Author), Jane Tomimori (Author), Marília Brasil Xavier (Author), Luiz Vicente Rizzo (Author), Esper Georges Kallas (Author), Karina Inácio Carvalho (Author)
Format: Book
Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
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Summary:Leprosy control is achieved through a fine-tuning of TH1 and TH2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the innate lymphoid cells compartment in peripheral blood of leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2 innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function.
Item Description:1935-2727
1935-2735
10.1371/journal.pntd.0004030

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