In vitro drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel

• Main Authors: Diarmaid J. Murphy (Author), Yahya H. Dallal Bashi (Author), Clare F. McCoy (Author), Peter Boyd (Author), Leeanne Brown (Author), François Martin (Author), Nicole McMullen (Author), Kyle Kleinbeck (Author), Bindi Dangi (Author), Patrick Spence (Author), Bashir Hansraj (Author), Bríd Devlin (Author), R. Karl Malcolm (Author)
• Format: Knjiga
• Izdano: Elsevier, 2022-12-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

We have previously reported a multipurpose silicone elastomer vaginal ring providing sustained release of dapivirine (an antiretroviral) and levonorgestrel (a progestin) for HIV prevention and hormonal contraception. During initial development, issues arose due to reaction between the ethynyl group...