Metabolic and Biochemical Effects of Pyrroloquinoline Quinone (PQQ) on Inflammation and Mitochondrial Dysfunction: Potential Health Benefits in Obesity and Future Perspectives

Obesity is defined as a complex, systemic disease characterized by excessive and dysfunctional adipose tissue, leading to adverse health effects. This condition is marked by low-grade inflammation, oxidative stress, and metabolic abnormalities, including mitochondrial dysfunction. These factors prom...

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Main Authors: Davide Charrier (Author), Giuseppe Cerullo (Author), Roberta Carpenito (Author), Vincenzo Vindigni (Author), Franco Bassetto (Author), Luca Simoni (Author), Tatiana Moro (Author), Antonio Paoli (Author)
Format: Book
Published: MDPI AG, 2024-08-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Davide Charrier  |e author 
700 1 0 |a Giuseppe Cerullo  |e author 
700 1 0 |a Roberta Carpenito  |e author 
700 1 0 |a Vincenzo Vindigni  |e author 
700 1 0 |a Franco Bassetto  |e author 
700 1 0 |a Luca Simoni  |e author 
700 1 0 |a Tatiana Moro  |e author 
700 1 0 |a Antonio Paoli  |e author 
245 0 0 |a Metabolic and Biochemical Effects of Pyrroloquinoline Quinone (PQQ) on Inflammation and Mitochondrial Dysfunction: Potential Health Benefits in Obesity and Future Perspectives 
260 |b MDPI AG,   |c 2024-08-01T00:00:00Z. 
500 |a 10.3390/antiox13091027 
500 |a 2076-3921 
520 |a Obesity is defined as a complex, systemic disease characterized by excessive and dysfunctional adipose tissue, leading to adverse health effects. This condition is marked by low-grade inflammation, oxidative stress, and metabolic abnormalities, including mitochondrial dysfunction. These factors promote energy dysregulation and impact body composition not only by increasing body fat but also by promoting skeletal muscle mass atrophy. The decline in muscle mass is associated with an increased risk of all-cause mortality in individuals with this disease. The European Food Safety Authority approved pyrroloquinoline quinone (PQQ), a natural compound, as a dietary supplement in 2018. This narrative review aims to provide a comprehensive overview of the potential role of PQQ, based on its anti-inflammatory and antioxidant properties, in addressing dysfunctional adipose tissue metabolism and related disorders. 
546 |a EN 
690 |a pyrroloquinoline quinone (PQQ) 
690 |a adipose tissue 
690 |a oxidative stress 
690 |a inflammation 
690 |a mitochondrial dysfunction 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Antioxidants, Vol 13, Iss 9, p 1027 (2024) 
787 0 |n https://www.mdpi.com/2076-3921/13/9/1027 
787 0 |n https://doaj.org/toc/2076-3921 
856 4 1 |u https://doaj.org/article/98f19a4bf8a94e5f91ba32d29dbdcc75  |z Connect to this object online.