Ubiquinone (Coenzyme Q-10) Supplementation Influences Exercise-Induced Changes in Serum 25(OH)D<sub>3</sub> and the Methyl-Arginine Metabolites: A Double-Blind Randomized Controlled Trial
Researchers have studied the effects of exercise on serum methyl-arginine and vitamin D metabolites; however, the effects of exercise combined with antioxidants are not well documented. Since oxidative stress affects the metabolism of vitamin D and methyl-arginine, we hypothesised that the antioxida...
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| Main Authors: | , , , , , , , , , |
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| Format: | Book |
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MDPI AG,
2024-06-01T00:00:00Z.
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| Summary: | Researchers have studied the effects of exercise on serum methyl-arginine and vitamin D metabolites; however, the effects of exercise combined with antioxidants are not well documented. Since oxidative stress affects the metabolism of vitamin D and methyl-arginine, we hypothesised that the antioxidant coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) might modulate exercise-induced changes. A group of twenty-eight healthy men participated in this study and were divided into two groups: an experimental group and a control group. The exercise test was performed until exhaustion, with gradually increasing intensity, before and after the 21-day CoQ<sub>10</sub> supplementation. Blood samples were collected before, immediately after, and 3 and 24 h after exercise. CoQ<sub>10</sub>, vitamin D metabolites, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine, methylarginine, dimethylamine, arginine, citrulline, and ornithine were analysed in serum samples. CoQ<sub>10</sub> supplementation caused a 2.76-fold increase in the concentration of serum CoQ<sub>10</sub>. Conversely, the 25(OH)D<sub>3</sub> concentration increased after exercise only in the placebo group. ADMA increased after exercise before supplementation, but a decrease was observed in the CoQ<sub>10</sub> supplementation group 24 h after exercise. In conclusion, our data indicate that CoQ<sub>10</sub> supplementation modifies the effects of exercise on vitamin D and methyl-arginine metabolism, suggesting its beneficial effects. These findings contribute to the understanding of how antioxidants like CoQ<sub>10</sub> can modulate biochemical responses to exercise, potentially offering new insights for enhancing athletic performance and recovery. |
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| Item Description: | 10.3390/antiox13070760 2076-3921 |