Acute fulminant drug induced necrotizing pancreatitis in a patient with ankylosing spondylitis

Drug-induced acute necrotizing pancreatitis is a rare adverse event, although it has been reported in association with different drugs, including non-steroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, and analgesic agents commonly used in rheumatology. In different reviews of...

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Main Authors: Pablo Miramontes (Author), Carlos Montilla (Author), Ismael Calero-Paniagua (Author), Andrés Plata (Author)
Format: Book
Published: Sociedade Galega de Medicina Interna, 2015-03-01T00:00:00Z.
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Summary:Drug-induced acute necrotizing pancreatitis is a rare adverse event, although it has been reported in association with different drugs, including non-steroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, and analgesic agents commonly used in rheumatology. In different reviews of the pancreotoxicity of drugs, infliximab and etanercept are mentioned among all medications implicated in drug-induced pancreatitis, but clinical cases of acute pancreatitis complicating treatment with these anti-TNF-α agents have been exceptionally reported. We describe a patient with ankylosing spondylitis treated with etanercept, who developed an acute fulminant necrotizing pancreatitis that resulted in death. Doctors should pay close attention to patients taking biologic drugs in which a complaint of abdominal pain lasting for several days with no apparent cause may require a prompt referral for medical consultation.
Item Description:0304-4866
1989-3922
10.22546/31/685