Design and Evaluation of S-Protected Thiolated-Based Itopride Hydrochloride Polymeric Nanocrystals for Functional Dyspepsia: QbD-Driven Optimization, In Situ, In Vitro, and In Vivo Investigation

• Main Authors: Moutaz Y. Badr (Author), Pratap Basim (Author), Khaled M. Hosny (Author), Waleed Y. Rizg (Author), N. Raghavendra Naveen (Author), Mallesh Kurakula (Author), Fayez Alsulaimani (Author), Awaji Y. Safhi (Author), Fahad Y. Sabei (Author), Mohammed Alissa (Author), Abdulmohsin J. Alamoudi (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mucoadhesive nanosized crystalline aggregates (NCs) can be delivered by the gastrointestinal, nasal, or pulmonary route to improve retention at particular sites. Itopride hydrochloride (ITH) was selected as a drug candidate due to its absorption from the upper gastrointestinal tract. For drug locali...