Structural biology of HER2/ERBB2 dimerization: mechanistic insights and differential roles in healthy versus cancerous cells

• 主要な著者: Jayasree Santhanakrishnan (著者), Prabhu Meganathan (著者), Hemamalini Vedagiri (著者)
• フォーマット: 図書
• 出版事項: Open Exploration Publishing Inc., 2024-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Aim: Present study was done to understand the dimerization of HER2/ERBB2 in normal and cancer cells using in-silico study. Methods: Pathway analysis was done using Reactome. Structure of HER2/ERBB2 protein was obtained from PDB database, and using Schrödinger software protein structure was analysed...