Structural biology of HER2/ERBB2 dimerization: mechanistic insights and differential roles in healthy versus cancerous cells

• Ngā kaituhi matua: Jayasree Santhanakrishnan (Author), Prabhu Meganathan (Author), Hemamalini Vedagiri (Author)
• Hōputu: Pukapuka
• I whakaputaina: Open Exploration Publishing Inc., 2024-07-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Aim: Present study was done to understand the dimerization of HER2/ERBB2 in normal and cancer cells using in-silico study. Methods: Pathway analysis was done using Reactome. Structure of HER2/ERBB2 protein was obtained from PDB database, and using Schrödinger software protein structure was analysed...