Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time

• Main Authors: Tam Ly (Author), Jyoti Gulia (Author), Vasilios Pyrgos (Author), Masashi Waga (Author), Shmuel Shoham (Author)
• Format: Book
• Published: Dove Medical Press, 2008-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Tam Ly, Jyoti Gulia, Vasilios Pyrgos, Masashi Waga, Shmuel ShohamSection of Infectious Diseases, Washington Hospital Center, Washington DC, USAAbstract: Fluorescence in situ hybridization using peptide nucleic acid probes (PNA-FISH) differentiates Staphylococcus aureus from other Gram-positive-cocci in clusters (GPCC). 101/202 patients with GPCC+ blood cultures were randomly assigned to clinician-notification of PNA FISH results. Notifi cation was associated with reduced mortality (8% vs.17%, p = 0.05), further antibiotic use (median −2.5 days, p = 0.01), and trended toward reduced hospital stay and charges.

Item Description

1176-6336
1178-203X