Cover Image

A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors

Eukaryotic elongation factor 2 kinase (eEF2K) inhibitors may aid in the development of new therapeutic agents to combat cancer. Purified human eEF2K was obtained from an Escherichia coli expression system and a luminescence-based high-throughput screening (HTS) assay was developed using MH-1 peptide...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ting Xiao (Author), Rui Liu (Author), Christopher G. Proud (Author), Ming-Wei Wang (Author)
Format:	Book
Published:	Elsevier, 2016-10-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Mechanisms underlying the relaxation by A484954, a eukaryotic elongation factor 2 kinase inhibitor, in rat isolated mesenteric artery
by: Tomoko Kodama, et al.
Published: (2018)

Eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood pressure in spontaneously hypertensive rats via inducing vasorelaxation
by: Tomoko Kodama, et al.
Published: (2020)

Stress-Based High-Throughput Screening Assays to Identify Inhibitors of Cell Envelope Biogenesis
by: Maurice Steenhuis, et al.
Published: (2020)

Assay development and high-throughput screening for small molecule inhibitors of a Vibrio cholerae stress response pathway
by: Stanbery L, et al.
Published: (2017)

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.
by: Roderick G Walker, et al.
Published: (2011)

An in silico high-throughput screen identifies potential selective inhibitors for the non-receptor tyrosine kinase Pyk2
by: Meirson T, et al.
Published: (2017)

High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway
by: Elita Yuliantie, et al.
Published: (2018)

Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor library.
by: Deu John M Cruz, et al.
Published: (2013)

Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors
by: Markus Schweipert, et al.
Published: (2023)

A High Throughput Cell-Based Screen Assay for LINE-1 ORF1p Expression Inhibitors Using the In-Cell Western Technique
by: Yanni Kou, et al.
Published: (2022)

High-yield synthesis and purification of recombinant human GABA transaminase for high-throughput screening assays
by: Mingu Gordon Park, et al.
Published: (2021)

DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening
by: Mingu Gordon Park, et al.
Published: (2023)

High-Throughput Phenotypic Assay to Screen for Anthelmintic Activity on <i>Haemonchus contortus</i>
by: Aya C. Taki, et al.
Published: (2021)

Establishment and application of a high-throughput screening model for cell adhesion inhibitors
by: Han Sun, et al.
Published: (2023)

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade.
by: Anton Simeonov, et al.
Published: (2008)

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.
by: Dana M Klug, et al.
Published: (2019)

Cryopreservation in Eukaryotes
Published: (2016)

High-throughput assays to assess variant effects on disease
by: Kaiyue Ma, et al.
Published: (2024)

Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening
by: Chlebowicz J, et al.
Published: (2023)

A high-throughput assay for screening natural products that boost NK cell-mediated killing of cancer cells
by: Zihang Xu, et al.
Published: (2020)

Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening
by: Mezencev Roman, et al.
Published: (2012)

Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening
by: Albertus Eka Yudistira Sarwono, et al.
Published: (2019)

A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer
by: Yang Liu, et al.
Published: (2023)

A direct, sensitive and high-throughput genus and species-specific molecular assay for large-scale malaria screening
by: Yaling Zhao, et al.
Published: (2022)

High-Throughput Screening for Drug Discovery
Published: (2022)

Identification of dihydrogambogic acid as a matrix metalloproteinase 1 inhibitor by high-throughput screening
by: Li Y, et al.
Published: (2017)

Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors
by: Rachel H. Clare, et al.
Published: (2024)

Quality control of cell-based high-throughput drug screening
by: Zhiyun Zhang, et al.
Published: (2012)

A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility.
by: Michael J Smout, et al.
Published: (2010)

High-throughput screening assay used in pharmacognosy: Selection, optimization and validation of methods of enzymatic inhibition by UV-visible spectrophotometry
by: Graciela Granados-Guzmán, et al.
Published: (2014)

Optimisation and Validation of a High Throughput Screening Compatible Assay to Identify Inhibitors of the Plasma Membrane Calcium ATPase Pump - a Novel Therapeutic Target for Contraception and Malaria
by: Tamer M A Mohamed, et al.
Published: (2013)

Screening of Mineralogenic and Osteogenic Compounds in Zebrafish-Tools to Improve Assay Throughput and Data Accuracy
by: Joana T. Rosa, et al.
Published: (2022)

Discovery of Novel Chemical Series of OXA-48 β-Lactamase Inhibitors by High-Throughput Screening
by: Barbara Garofalo, et al.
Published: (2021)

Development and validation of a yeast high-throughput screen for inhibitors of Aβ42 oligomerization
by: Sei-Kyoung Park, et al.
Published: (2011)

In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds.
by: Adriana M C Canavaci, et al.
Published: (2010)

Validation of a high-throughput and robust technique: BACs-on-beads assay (KaryoLite BoBs) for pre-implantation aneuploidy screening
by: Grace Wing Shan Kong, et al.
Published: (2017)

A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors
by: Yihui Song, et al.
Published: (2021)

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.
by: Andrea Nühs, et al.
Published: (2015)

Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni.
by: Cristiana Lalli, et al.
Published: (2015)

High-throughput virtual screening with e-pharmacophore and molecular simulations study in the designing of pancreatic lipase inhibitors
by: Veeramachaneni GK, et al.
Published: (2015)