IPEX as a Consequence of Alternatively Spliced FOXP3
The transcription factor FOXP3 controls the immunosuppressive program in CD4+ T cells that is crucial for systemic immune regulation. Mutations of the single X-chromosomal FOXP3 gene in male individuals cause the inherited autoimmune disease immune dysregulation, polyendocrinopathy, enteropathy, and...
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Frontiers Media S.A.,
2020-10-01T00:00:00Z.
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