Erythropoietin attenuates pulmonary vascular remodeling in experimental pulmonary arterial hypertension through interplay between endothelial progenitor cells and heme-oxygenase

• Main Authors: Rosa L.E. Loon (Author), Beatrijs eBartelds (Author), Frank A.D.T.G. Wagener (Author), Nada eAffara (Author), Saffloer eMohaupt (Author), Hans eWijnberg (Author), Sebastiaan W.C. Pennings (Author), Janny eTakens (Author), Rolf M.F. Berger (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundPulmonary arterial hypertension (PAH) is a pulmonary vascular disease with a high mortality, characterized by typical angio-proliferative lesions. Erythropoietin (EPO) attenuates pulmonary vascular remodeling in PAH. We postulated that EPO acts through mobilization of endothelial progenito...