Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework

• Main Authors: Romain Ollier (Author), Aline Fuchs (Author), Florence Gauye (Author), Katarzyna Piorkowska (Author), Sébastien Menant (Author), Monisha Ratnam (Author), Paolo Montanari (Author), Florence Guilhot (Author), Didier Phillipe (Author), Mickael Audrain (Author), Anne-Laure Egesipe (Author), Damien Névoltris (Author), Tamara Seredenina (Author), Andrea Pfeifer (Author), Marie Kosco-Vilbois (Author), Tariq Afroz (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTOptimal pharmacokinetic (PK) properties of therapeutic monoclonal antibodies (mAbs) are essential to achieve the desired pharmacological benefits in patients. To accomplish this, we followed an approach comprising structure-based mAb charge engineering in conjunction with the use of relevant...