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Anti-osteoporosis Effect of 5-Bromo-2-(4-chlorobenzoyl)-(Z)-3-(2-cyano-3-hydroxybut-2-enonyl)aminobenzo[b]furan: a Novel Selective Estrogen Receptor Modulator

Abstract.: The benzo[b]furan derivative MU314 inhibits in vitro bone resorption as potently as β-estradiol (E2). Here, we examined the point of action on the anti-osteoporotic effects of MU314. MU314 (10 nM) suppressed lacunae formation by osteoclastic cells and ICI-182,780, a pure E2 antagonist, in...

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Main Authors:	Ryo Fukuyama (Author), Akio Shimokawa (Author), Yasushi Kodama (Author), Mitsugu Fujita (Author), Yoshitaka Ohishi (Author), Yuko Ando (Author), Masao Koida (Author), Hiromichi Nakamuta (Author)
Format:	Book
Published:	Elsevier, 2011-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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