Impact of Guidelines Regarding Dihydropyrimidine Dehydrogenase (DPD) Deficiency Screening Using Uracil-Based Phenotyping on the Reduction of Severe Side Effect of 5-Fluorouracil-Based Chemotherapy: A Propension Score Analysis

• Main Authors: Nicolas Laures (Author), Céline Konecki (Author), Mathias Brugel (Author), Anne-Lise Giffard (Author), Naceur Abdelli (Author), Damien Botsen (Author), Claire Carlier (Author), Claire Gozalo (Author), Catherine Feliu (Author), Florian Slimano (Author), Zoubir Djerada (Author), Olivier Bouché (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with severe fluoropyrimidines-induced toxicity. As of September 2018, French recommendations call for screening for DPD deficiency by plasma uracil quantification prior to all fluoropyrimidine-based chemotherapy. A dose reduction of fluo...