Future Perspective for ALK-Positive Anaplastic Large Cell Lymphoma with Initial Central Nervous System (CNS) Involvement: Could Next-Generation ALK Inhibitors Replace Brain Radiotherapy for the Prevention of Further CNS Relapse?

• Main Authors: Makito Tanaka (Author), Hiroki Miura (Author), Soichiro Ishimaru (Author), Gen Furukawa (Author), Yoshiki Kawamura (Author), Kei Kozawa (Author), Seiji Yamada (Author), Fumitaka Ito (Author), Kazuko Kudo (Author), Tetsushi Yoshikawa (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Central nervous system (CNS) involvement in anaplastic large cell lymphoma (ALCL) at diagnosis is rare and leads to poor prognosis with the use of the standard ALCL99 protocol alone. CNS-directed intensive chemotherapy, such as an increased dose of intravenous MTX, increased dose of dexamethasone, i...