New Approaches to Blockade of the Renin-Angiotensin-Aldosterone System: Chymase as an Important Target to Prevent Organ Damage
Chymase plays a crucial role in angiotensin II formation in various tissues. Angiotensin II induces gene expression of transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors, and chymase can convert precursors of TGF-β and MMP-9 to their active forms. In cultured fibrobla...
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| Main Authors: | , , |
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| Format: | Book |
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Elsevier,
2010-01-01T00:00:00Z.
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