In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST4 Receptor Agonists

• Main Authors: Boglárka Kántás (Author), Éva Szőke (Author), Rita Börzsei (Author), Péter Bánhegyi (Author), Junaid Asghar (Author), Lina Hudhud (Author), Anita Steib (Author), Ágnes Hunyady (Author), Ádám Horváth (Author), Angéla Kecskés (Author), Éva Borbély (Author), Csaba Hetényi (Author), Gábor Pethő (Author), Erika Pintér (Author), Zsuzsanna Helyes (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via its receptor subtype 4 (SST4) without influencing endocrine functions. Therefore, SST4 is considered to be a novel target for drug development in pain, especially chroni...