Effect of turmeric extract on bone healing in an experimental model of femoral bone fracture

• Main Authors: Shahab Ilka (Author), Afshin Heshmati (Author), Seyed Alireza Mirabdollahi (Author), Abdollah Jafarzadeh (Author), Farnaz Sedghy (Author), Fatemeh Bagheri (Author), Omid Azari (Author), Mohammad Ali Mohammadi (Author), Fatemeh Jafari Dareh Dar (Author), Moein Arabnadvi (Author)
• Format: Book
• Published: Mashhad University of Medical Sciences, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objective: Following bone trauma, several factors participate in making a balance between the activity of osteoblasts and osteoclasts. The receptor activator of nuclear factor kappa B ligand (RANKL), receptor activator of nuclear factor kappa B (RANK), and osteoprotegerin (OPG) molecules play critical roles in the healing process via regulation of osteoclasts function. Turmeric is suggested to have an anti-osteogenic potential; however, its effect on accelerating bone healing has not been adequately studied. Here, we used a rat model of femur fracture to explore the effect of treatment with turmeric extract on the bone repair and the expression of RANK, RANKL, and OPG molecules.Materials and methods: Eight rats were subjected to surgery, randomly divided into two groups, and treated orally with turmeric (200 mg/kg), or olive oil. Four oil-treated rats without bone fracture were used as control group. After six weeks of treatment, the femurs of animals were examined for radiological, histological, and gene expression analysis.Results: X-ray radiography showed thicker callus and a more obscure fracture line in the turmeric group. Furthermore, higher osteoblast percentages but no osteoclasts were observed in turmeric-treated animals, representing better repair of bone in the fracture site. Also, real-time analyses showed that treatment with turmeric reduced RANK and RANKL expression (p <0.0001) and lowered RANKL/OPG ratio (p=0.01) in femoral bone tissue.Conclusion: Our findings indicated the turmeric ability to facilitate bone hemostasis and optimize the expression of key markers involved in the bone metabolism.

Item Description

2228-7930
2228-7949
10.22038/ajp.2021.18561