Insulin resistance and associated factors in healthy volunteers in South-west Nigeria

• Main Authors: EN Adejumo (Author), OA Adejumo (Author), OA Ogundahunsi (Author)
• Format: Book
• Published: Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background: Insulin resistance (IR) is linked with the pathophysiology of some non-communicable diseases including Type 2 Diabetes mellitus and metabolic syndrome. Objective: To determine the factors associated with IR among apparently healthy individuals in South-west Nigeria. Methods: A cross-sectional study of a cohort of apparently healthy volunteers aged 18 years and above consecutively recruited from two communities was conducted. IR was determined using the homeostasis model assessment for IR (HOMA-IR) based on the cut off values of ≥ 2. Bivariate and multivariate analyses were used to determine the crude and adjusted odds ratio of IR associated factors. Results: A total of 520 participants aged 18-89 years were recruited for the study. Their mean age was 46.7±14.6 years and the prevalence of IR was 43.5%. Alcohol intake (AOR = 2.1, 95%CI 1.3 - 3.4; p<0.001), lack of physical exercise (AOR = 1.5, 95%CI 1.0 - 2.3), and Body Mass Index (AOR = 1.03, 95%CI 1.0 - 1.1) were the factors associated with IR. Conclusion: The prevalence of IR among apparently healthy individuals in this study was high. The need for proactive measures to avert the sequelae of IR is of utmost importance.

Item Description

10.30442/ahr.0602-03-76
2476-8642
2536-6149