Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal Formulation

• Hauptverfasser: Andreas Ouranidis (VerfasserIn), Nikos Gkampelis (VerfasserIn), Elisavet Vardaka (VerfasserIn), Anna Karagianni (VerfasserIn), Dimitrios Tsiptsios (VerfasserIn), Ioannis Nikolakakis (VerfasserIn), Kyriakos Kachrimanis (VerfasserIn)
• Format: Buch
• Veröffentlicht: MDPI AG, 2020-10-01T00:00:00Z.
• Schlagworte: article
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Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions in order to overcome the solubility barrier of BCS Class II substances. However, the application of mechanically and thermally intensive processes is not...