HPOAnnotator: improving large-scale prediction of HPO annotations by low-rank approximation with HPO semantic similarities and multiple PPI networks

• Main Authors: Junning Gao (Author), Lizhi Liu (Author), Shuwei Yao (Author), Xiaodi Huang (Author), Hiroshi Mamitsuka (Author), Shanfeng Zhu (Author)
• Formato: Livro
• Publicado em: BMC, 2019-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background As a standardized vocabulary of phenotypic abnormalities associated with human diseases, the Human Phenotype Ontology (HPO) has been widely used by researchers to annotate phenotypes of genes/proteins. For saving the cost and time spent on experiments, many computational approach...