Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016-2017.

• Những tác giả chính: Sangay Zangmo (Tác giả), Jit Bdr Darnal (Tác giả), Tsheten (Tác giả), Sonam Gyeltshen (Tác giả), Binay Thapa Thapa (Tác giả), Prinyada Rodpradit (Tác giả), Piyawan Chinnawirotpisan (Tác giả), Wudtichai Manasatienkij (Tác giả), Louis R Macareo (Tác giả), Stefan Fernandez (Tác giả), Sonam Wangchuk (Tác giả), Chonticha Klungthong (Tác giả)
• Định dạng: Sách
• Được phát hành: Public Library of Science (PLoS), 2020-04-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.
• Notes: 1935-2727; 1935-2735; 10.1371/journal.pntd.0008165
• Keywords: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270
• Source: PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008165 (2020)

Dengue continues to pose a significant public health problem in tropical and subtropical countries. In Bhutan, first outbreak of dengue fever (DF) was reported in 2004 in a southern border town, followed by sporadic cases over the years. In this study, we analysed DF outbreaks that occurred in 3 different places during the years 2016 and 2017. A total of 533 cases in 2016 and 163 in 2017 were suspected of having of DF, where young adults were mostly affected. A total of 240 acute serum specimens collected and analyzed for serotype by nested RT-PCR revealed predominance of serotypes 1 and 2 (DENV-1 and 2). Phylogenetic analysis using envelope gene for both the serotypes demonstrated cosmopolitan genotype which were closely related to strains from India, indicating that they were probably imported from the neighboring country over the past few years.