Cover Image

Antitumour activity of 1,1-bis-(pyrimidine-2,4-diono-1-il)-2-bromo-2-chloroethylenes substituted molecular complexes and bacterial lectin

The aim of research. One of the most successful directions of new antitumour preparations finding is the investigation of antimetabolites of pyrimidin's and purin's change which forwards as preformed compounds at the link of biosynthetic processes (DNA, RNA, specific proteins) and brakes t...

Full description

Saved in:

Bibliographic Details
Main Author:	E. V. Welchinska (Author)
Format:	Book
Published:	Zaporozhye State Medical University, 2015-04-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives
by: Jean Guillon, et al.
Published: (2020)

New 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline Derivatives: Synthesis and Biological Evaluation as Novel Anticancer Agents by Targeting G-Quadruplex
by: Jean Guillon, et al.
Published: (2023)

Synthesis of new alkyl derivatives of N(1)-(2'-bromo-1',1'-difluoro-2'-chloroethyl)uracil with potential antitumor activity
by: O. V. Velchynska
Published: (2020)

The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones
by: Yevhen Karpun, et al.
Published: (2021)

Synthesis of Some 1,4-Bis (Substituted 1,3,4-Oxadiazoles and 1,2,4-Triazoles) Benzene From Terephthalic Acid
by: K. Daoud, et al.
Published: (1999)

QSAR prediction of toxicity for a new 1,2,4-triazole derivatives with 2-bromo-5-methoxyphenyl fragment
by: M. P. Skoryi, et al.
Published: (2024)

Design and optimization of piperidine-substituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles
by: Yanying Sun, et al.
Published: (2024)

Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs
by: Dongwei Kang, et al.
Published: (2020)

Synthesis and antitumor activity of 1,3,4-oxadiazole substituted 2-(5-ylidene-2,4-dioxothiazolidin-3-yl)-acetamides
by: Maryan Lelyukh, et al.
Published: (2023)

A Fluorinated Analogue of Marine Bisindole Alkaloid 2,2-Bis(6-bromo-1<i>H</i>-indol-3-yl)ethanamine as Potential Anti-Biofilm Agent and Antibiotic Adjuvant Against <i>Staphylococcus aureus</i>
by: Raffaella Campana, et al.
Published: (2020)

Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
by: Betül Kaya, et al.
Published: (2017)

Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylate
by: Shaima S. Ismmaeel
Published: (2018)

Design and synthesis of some substituted thiazolo[3,2-a]pyrimidine derivatives of potential biological activities
by: Samia G. Abdel Moty, et al.
Published: (2016)

4-Substituted Thieno[3,2-<i>d</i>]pyrimidines as Dual-Stage Antiplasmodial Derivatives
by: Prisca Lagardère, et al.
Published: (2022)

Synthesis, spectral analysis and pharmacological study of N'- substituted-2-(5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazides
by: Shahid Rasool, et al.

Synthesis and Pharmacological Evaluation of Some New Pyrimidine Derivatives Containing 1,2,4-Triazole
by: Shantaram Gajanan Khanage, et al.
Published: (2012)

ANALGETIC ACTIVITY OF SUBSTITUTED 1-(2-IMIDAZOLETHYL)-3- PYRROLINE-2-ONS
by: A. A. Ponomaryova, et al.
Published: (2015)

Synthesis, chemical and biological properties of the new mono- and bis-derivatives of imidazoles
by: E. V. Welchinska
Published: (2014)

5-Bromo-3-(3-hydroxyprop-1-ynyl)-2H-pyran-2-one targets prostate cancer cells by down-regulating inflammation-related genes
by: Zhao-Yang Wang, et al.
Published: (2016)

Synthesis, Evaluation of Cytotoxicity and Molecular Docking Studies of the 7-Acetamido Substituted 2-Aryl-5-bromo-3-trifluoroacetylindoles as Potential Inhibitors of Tubulin Polymerization
by: Malose J. Mphahlele, et al.
Published: (2018)

Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo
by: Shushan Ge, et al.
Published: (2020)

NOD1/2 and the C-Type Lectin Receptors Dectin-1 and Mincle Synergistically Enhance Proinflammatory Reactions Both In Vitro and In Vivo
by: Tukhvatulin AI, et al.
Published: (2020)

Synthesis and Study of Some fused Substituted 1,3,4-Thiadiazoles and 1,2,4-Triazoles from 4-Chloro- phenoxy acetic acid and 2,4-dichlorophenoxy acetic acid
by: Mudhar Othman
Published: (2020)

(±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H2O2 Through Activation of Nrf2 Pathway
by: Saidan Qi, et al.
Published: (2022)

Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity
by: Asmaa A. Mandour, et al.
Published: (2022)

Analgesic Activity of Some 1,2,4-Triazole Heterocycles Clubbed with Pyrazole, Tetrazole, Isoxazole and Pyrimidine
by: Ramdas Bhanudas Pandhare, et al.
Published: (2013)

A crystallographic study of Bis[S-benzyl-5-bromo- 2-oxoindolin-3- lidenemethanehydrazonthioate] disulfide solvated with dimethylsulfoxide / Mohd Abdul Fatah Abdul Manan ... [et al.]
by: Abdul Manan, Mohd Abdul Fatah, et al.
Published: (2012)

The Synthesis, Antimicrobial Activity, and Molecular Docking of New 1, 2, 4-Triazole, 1, 2, 4-Triazepine, Quinoline, and Pyrimidine Scaffolds Condensed to Naturally Occurring Furochromones
by: Ameen Ali Abu-Hashem, et al.
Published: (2022)

1,2-Bis[(3-methoxyphenyl)methyl]ethane-1,2-Dicarboxylic Acid Reduces UVB-Induced Photodamage In Vitro and In Vivo
by: Po-Yuan Wu, et al.
Published: (2019)

2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm.
by: Frederick A Partridge, et al.
Published: (2018)

Design and biological evaluation of 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2-TK inhibitors
by: Abdelfattah Hassan, et al.
Published: (2023)

Synthesis Some of New Substituted 1,3,4-Thiadiazole and 1,2,4-Triazole
by: Tamara alsafar, et al.
Published: (2020)

Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles
by: Shereen R. Mohamed
Published: (2009)

Synthesis, in vitro antitumour activity, and molecular docking study of novel 2-substituted mercapto-3-(3,4,5-trimethoxybenzyl)-4(3H)-quinazolinone analogues
by: Adel S. El-Azab, et al.
Published: (2017)

Synthesis of 2,7-diarylpyrazolo [1,5-a] pyrimidine derivatives with antitumor activity. Theoretical identification of targets
by: Andrés Ballesteros-Casallas, et al.
Published: (2022)

Synthesis Of Some Substituted 1,2,5-Oxadiazino [2-3,b] Quinazoline And Some 1,3-Oxazole Derivatives
by: Yassir S. Mohamad
Published: (2013)

Antimicrobial and Antifungal Activity of Rare Substituted 1,2,3-Thiaselenazoles and Corresponding Matched Pair 1,2,3-Dithiazoles
by: Tuomo Laitinen, et al.
Published: (2020)

A 2,3-diphenylpyrido[1,2-a] pyrimidin-4-one derivative inhibits specific angiogenic factors induced by TNF-α
by: Serena Del Turco, et al.
Published: (2019)

Synthesis and PASS-assisted in silico approach of some novel 2-substituted benzimidazole bearing a pyrimidine-2, 4, 6(trione) system as mucomembranous protector
by: Bijo Mathew, et al.
Published: (2013)

Synthesis of 2-(6-substituted quinolin-4-yl)-1-(4-aryl-1H-1,2,3-triazol-1-yl) propan-2-ol as potential antifungal and antitubercular agents
by: Abhijit Shinde, et al.
Published: (2023)