Development and application of a PBPK modeling strategy to support antimalarial drug development

• Main Authors: Nada Abla (Author), Eleanor Howgate (Author), Karen Rowland‐Yeo (Author), Maurice Dickins (Author), Mackenzie C. Bergagnini‐Kolev (Author), Kuan‐Fu Chen (Author), Savannah McFeely (Author), Jennifer J. Bonner (Author), Laura G. A. Santos (Author), Nathalie Gobeau (Author), Howard Burt (Author), Zoe Barter (Author), Hannah M. Jones (Author), David Wesche (Author), Susan A. Charman (Author), Jörg J. Möhrle (Author), Jeremy N. Burrows (Author), Lisa M. Almond (Author)
• Format: Book
• Published: Wiley, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract As part of a collaboration between Medicines for Malaria Venture (MMV), Certara UK and Monash University, physiologically‐based pharmacokinetic (PBPK) models were developed for 20 antimalarials, using data obtained from standardized in vitro assays and clinical studies within the literature...