Cefdinir and β-Lactamase Inhibitor Independent Efficacy Against Mycobacterium tuberculosis

• Main Authors: Shashikant Srivastava (Author), Tania Thomas (Author), Dave Howe (Author), Lesibana Malinga (Author), Prithvi Raj (Author), Jan-Willem Alffenaar (Author), Tawanda Gumbo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: There is renewed interest in repurposing β-lactam antibiotics for treatment of tuberculosis (TB). We investigated efficacy of cefdinir, that withstand the β-lactamase enzyme present in many bacteria, against drug-susceptible and multi-drug resistant (MDR) Mycobacterium tuberculosis (Mtb)...