Discovery of novel KRAS‒PDEδ inhibitors with potent activity in patient-derived human pancreatic tumor xenograft models
KRAS‒PDEδ interaction is revealed as a promising target for suppressing the function of mutant KRAS. The bottleneck in clinical development of PDEδ inhibitors is the poor antitumor activity of known chemotypes. Here, we identified novel spiro-cyclic PDEδ inhibitors with potent antitumor activity bot...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2022-01-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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