Microbial translocation is associated with extensive immune activation in dengue virus infected patients with severe disease.

• Main Authors: Cornelia A M van de Weg (Author), Cláudio S Pannuti (Author), Evaldo S A de Araújo (Author), Henk-Jan van den Ham (Author), Arno C Andeweg (Author), Lucy S V Boas (Author), Alvina C Felix (Author), Karina I Carvalho (Author), Andreia M de Matos (Author), José E Levi (Author), Camila M Romano (Author), Cristiane C Centrone (Author), Celia L de Lima Rodrigues (Author), Expedito Luna (Author), Eric C M van Gorp (Author), Albert D M E Osterhaus (Author), Byron E E Martina (Author), Esper G Kallas (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Severe dengue virus (DENV) disease is associated with extensive immune activation, characterized by a cytokine storm. Previously, elevated lipopolysaccharide (LPS) levels in dengue were found to correlate with clinical disease severity. In the present cross-sectional study we identified...