Alginate-pomegranate peels' polyphenols beads: effects of formulation parameters on loading efficiency

• Main Authors: Wissam Zam (Author), Ghada Bashour (Author), Wassim Abdelwahed (Author), Warid Khayata (Author)
• Format: Book
• Published: Universidade de São Paulo, 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2175-9790; 10.1590/S1984-82502014000400009
• Keywords: Romã/polifenóis/microencapsulação; Alginato de cálcio/microencapsulação; Microencapsulação; Polifenóis; Antioxidantes naturais/microencapsulação; Pharmacy and materia medica; RS1-441
• Source: Brazilian Journal of Pharmaceutical Sciences, Vol 50, Iss 4, Pp 741-748 (2014)

Calcium alginate beads containing pomegranate peels' polyphenol extract were encapsulated by ionic gelation method. The effects of various formulation factors (sodium alginate concentration, calcium chloride concentration, calcium chloride exposure time, gelling bath time maintaining, and extract concentration) on the efficiency of extract loading were investigated. The formulation containing an extract of 1 g pomegranate peels in 100 mL distilled water encapsulated with 3 % of sodium alginate cured in 0.05 M calcium chloride for 20 minutes and kept in a gelling bath for 15 minutes was chosen as the best formula regarding the loading efficiency. These optimized conditions allowed the encapsulation of 43.90% of total extracted polyphenols and 46.34 % of total extracted proanthocyanidins. Microencapsulation of pomegranate peels' extract in calcium alginate beads is a promising technique for pharmaceutical and food supplementation with natural antioxidants.