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n-3 Polyunsaturated Fatty Acid Supplementation Affects Oxidative Stress Marker Levels in Patients with Type II Intestinal Failure: A Randomized Double Blind Trial

Type II intestinal failure (IF-II) is a condition in which the gastrointestinal tract is compromised. Liver complications may occur because of the pathology and/or prolonged use of parenteral nutrition (PN); oxidative stress has been implicated as one of the causes. Lipid emulsions containing n-3 po...

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Main Authors: Adriana Flores-López (Author), Martha Guevara-Cruz (Author), Azalia Avila-Nava (Author), Alejandro G. González-Garay (Author), Luis E. González-Salazar (Author), Ana L. Reyes-Ramírez (Author), José Pedraza-Chaverri (Author), Omar N. Medina-Campos (Author), Isabel Medina-Vera (Author), Juan G. Reyes-García (Author), Armando R. Tovar (Author), Aurora E. Serralde-Zúñiga (Author)
Format: Book
Published: MDPI AG, 2023-07-01T00:00:00Z.
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Summary:Type II intestinal failure (IF-II) is a condition in which the gastrointestinal tract is compromised. Liver complications may occur because of the pathology and/or prolonged use of parenteral nutrition (PN); oxidative stress has been implicated as one of the causes. Lipid emulsions containing n-3 polyunsaturated fatty acids (PUFAs) have been proposed for the treatment. We aimed to evaluate the effect of 7-day n-3 PUFA supplementation on oxidative stress in IF-II patients receiving PN. This was a randomized, controlled, double-blinded, pilot trial of adult patients with IF-II, receiving either conventional PN (control) or PN enriched with n-3 PUFAs (intervention). Twenty patients were included (14 men, 49 ± 16.9 years), with the ANCOVA analysis the glucose (<i>p</i> = 0.003), and direct bilirubin (<i>p</i> = 0.001) levels reduced; whereas the high-density lipoprotein cholesterol (HDL-C) increased (<i>p</i> = 0.017). In the random-effect linear regression analysis, a reduction (<i>p</i> < 0.0001) in the malondialdehyde (MDA) level was found in the intervention group when the covariables age, HDL-C level, and alanine aminotransferase activity were considered. After 1 week of PN supplementation with n-3 PUFAs, the marker levels of some oxidative stress, blood lipids, and hepatic biomarkers improved in patients with IF-II.
Item Description:10.3390/antiox12081493
2076-3921

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