Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer's disease mouse model and proteomics analysis

• Main Authors: Xinhua Zhou (Author), Kaipeng Huang (Author), Yuqiang Wang (Author), Zaijun Zhang (Author), Yingying Liu (Author), Qinghua Hou (Author), Xifei Yang (Author), Maggie Pui Man Hoi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pathophysiology of Alzheimer's disease (AD) is multifactorial with characteristic extracellular accumulation of amyloid-beta (Aβ) and intraneuronal aggregation of hyperphosphorylated tau in the brain. Development of disease-modifying treatment for AD has been challenging. Recent studies sug...