A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion Formulation Development

• Main Authors: Samuel O. Kyeremateng (Author), Kristin Voges (Author), Stefanie Dohrn (Author), Ekaterina Sobich (Author), Ute Lander (Author), Stefan Weber (Author), David Gessner (Author), Rachel C. Evans (Author), Matthias Degenhardt (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several literature publications have described the potential application of active pharmaceutical ingredient (API)-polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD) formulations via the hot-melt extrusion (HME) technique. However, syste...