In-Line UV-Vis Spectroscopy as a Fast-Working Process Analytical Technology (PAT) during Early Phase Product Development Using Hot Melt Extrusion (HME)

• Κύριοι συγγραφείς: Walkiria Schlindwein (Συγγραφέας), Mariana Bezerra (Συγγραφέας), Juan Almeida (Συγγραφέας), Andreas Berghaus (Συγγραφέας), Martin Owen (Συγγραφέας), Gordon Muirhead (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2018-09-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

This paper displays the potential of an in-line PAT system for early phase product development during pharmaceutical continuous manufacturing following a Quality by Design (QbD) framework. Hot melt extrusion (HME) is used as continuous manufacturing process and UV–Vis spectroscopy as an in-line moni...