Proof of Concept: Matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes

• Main Authors: Frankwich Karen (Author), Tibble Courtney (Author), Torres-Gonzalez Moises (Author), Bonner Mariah (Author), Lefkowitz Roy (Author), Tyndall Matt (Author), Schmid-Schönbein Geert W (Author), Villarreal Francisco (Author), Heller Mike (Author), Herbst Karen (Author)
• Format: Book
• Published: BMC, 2012-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Obesity is a state of subclinical inflammation resulting in loss of function of insulin receptors and decreased insulin sensitivity. Inhibition of the inflammatory enzymes, matrix metalloproteinases (MMPs), for 6 months in rodent mod...