Bone marrow biopsy in non-Hodgkin lymphoma: A morphological study
<b>Context:</b> Bone marrow (BM) biopsy is an integral part of staging work-up for non-Hodgkin lymphoma (NHL). <b> Aims:</b> To study the characteristics of BM involvement in NHL with respect to incidence, histologic pattern and morphology of infiltration and its discordance...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Wolters Kluwer Medknow Publications,
2009-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | <b>Context:</b> Bone marrow (BM) biopsy is an integral part of staging work-up for non-Hodgkin lymphoma (NHL). <b> Aims:</b> To study the characteristics of BM involvement in NHL with respect to incidence, histologic pattern and morphology of infiltration and its discordance with the histology of primary anatomic site. <b> Settings and Design: </b> Forty-nine cases of NHL in which BM biopsy was performed for staging were included in this study, the primary site being classified according to the WHO classification for NHL. <b>Materials and Methods:</b> A prospective study of 49 cases was conducted. Bilateral BM biopsy was obtained from the posterior superior iliac spine. The biopsies were fixed in 10% buffered formalin solution and decalcified using 10% formal <i>-</i> formic acid for 4 <i>-</i> 6 h followed by routine processing. The serial sections were stained by hematoxylin and eosin and reticulin stains. <b> Results:</b> BM biopsy showed involvement by lymphoma in 27 cases (55.10%). Unilateral positivity was found in four cases (14.81% cases). The overall incidence of marrow involvement by NHL was 55.1%. The incidence of involvement was higher in T-cell lymphomas when compared with B-cell lymphomas and predominant pattern of involvement was mixed. Diffuse large B-cell lymphomas had the lowest incidence in all the B-cell lymphomas. A discordant histology between BM and primary anatomic site was found in 29.63% (8/27) of the cases, where it was seen more in follicular lymphomas and diffuse large B-cell lymphomas. <b> Conclusions:</b> Critical examination of BM biopsies can increase the diagnostic accuracy, thereby contributing to the prognosis and appropriate treatment modalities. |
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| Item Description: | 0377-4929 |