Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury

• Main Authors: Natasha Irrera (Author), Gabriele Pizzino (Author), Margherita Calò (Author), Giovanni Pallio (Author), Federica Mannino (Author), Fausto Famà (Author), Vincenzo Arcoraci (Author), Vincenzo Fodale (Author), Antonio David (Author), Cosentino Francesca (Author), Letteria Minutoli (Author), Emanuela Mazzon (Author), Placido Bramanti (Author), Francesco Squadrito (Author), Domenica Altavilla (Author), Alessandra Bitto (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment for traumatic brain injury (TBI) remains elusive despite compelling evidence from animal models for a variety of therapeutic targets. The activation of the NLRP3 (Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3) inflammasome has been proposed as key...