Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia

Acquired amegakaryocytic thrombocytopenia (AAMT) is a rare hematological disorder characterized by prolonged, severe thrombocytopenia, and reduced megakaryocytes on otherwise normal bone marrow biopsy. We report three cases of which two ultimately responded to treatment with eltrombopag, and one who...

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Main Authors: Amina Anwar (Author), Zena Chahine (Author), Dava Piecoro (Author), Melissa Kesler (Author), Ayman Qasrawi (Author)
Format: Book
Published: Elsevier, 2023-09-01T00:00:00Z.
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100 1 0 |a Amina Anwar  |e author 
700 1 0 |a Zena Chahine  |e author 
700 1 0 |a Dava Piecoro  |e author 
700 1 0 |a Melissa Kesler  |e author 
700 1 0 |a Ayman Qasrawi  |e author 
245 0 0 |a Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia 
260 |b Elsevier,   |c 2023-09-01T00:00:00Z. 
500 |a 2772-736X 
500 |a 10.1016/j.hpr.2023.300713 
520 |a Acquired amegakaryocytic thrombocytopenia (AAMT) is a rare hematological disorder characterized by prolonged, severe thrombocytopenia, and reduced megakaryocytes on otherwise normal bone marrow biopsy. We report three cases of which two ultimately responded to treatment with eltrombopag, and one who one succumbed to illness despite treatment with multiple agents. These cases emphasize the difficulty of diagnosis and treatment of this rare condition. 
546 |a EN 
690 |a Platelet disorder 
690 |a Diminished or absent megakaryopoiesis 
690 |a Rare hematological condition 
690 |a Pathology 
690 |a RB1-214 
655 7 |a article  |2 local 
786 0 |n Human Pathology Reports, Vol 33, Iss , Pp 300713- (2023) 
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