<i>CYP3A5*3</i> and <i>CYP3A4*22</i> Cluster Polymorphism Effects on LCP-Tac Tacrolimus Exposure: Population Pharmacokinetic Approach

• Main Authors: Zeyar Mohammed Ali (Author), Marinda Meertens (Author), Beatriz Fernández (Author), Pere Fontova (Author), Anna Vidal-Alabró (Author), Raul Rigo-Bonnin (Author), Edoardo Melilli (Author), Josep M. Cruzado (Author), Josep M. Grinyó (Author), Helena Colom (Author), Nuria Lloberas (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the study is to develop a population pharmacokinetic (PopPK) model and to investigate the influence of CYP3A5/CYP3A4 and ABCB1 single nucleotide polymorphisms (SNPs) on the Tacrolimus PK parameters after LCP-Tac formulation in stable adult renal transplant patients. The model was develope...