Effect of Vitamins A, E, C and Omega-3 Fatty Acids on Lipid Peroxidation in Streptozotocin Induced Diabetic Rats

• Main Authors: SH Fakher (Author), M Djalali (Author), SMB Tabei (Author), H Zeraati (Author), E Javadi (Author), MR Sadeghi (Author), E Mostafavi (Author), F Fatehi (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2007-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2251-6085
• Keywords: Vitamin A; Omega3 fatty acid; Public aspects of medicine; RA1-1270
• Source: Iranian Journal of Public Health, Vol 36, Iss 2, Pp 58-63 (2007)

Background: To assess the effect of supplementation with vitamins A, E and C and &#969;-3 fatty acids on lipid peroxidation in strepto¬zotocin (STZ) induced diabetic rats. Methods: Sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, dia¬betic with vitamin A, E as well as C supplementation and diabetic with &#969;-3 fatty acids supplementation. After four weeks of treat¬ment the rats were anesthetized and malondialdehyde (MDA) levels were investigated in blood samples, liver and heart ho¬mogenate. Results: In diabetic rats MDA level in plasma, liver and heart was significantly more elevated than normal control rats (P< 0.05). Vitamin A, E and C supplementation caused significant decrease in plasma, liver and heart MDA (P< 0.05). A signifi¬cant decrease in heart MDA (P< 0.05) was observed in diabetic rats with &#969;-3 fatty acids supplementation. Conclusion: Supplementation of vitamin A, E and C and &#969;-3 fatty acids was found to decrease lipid peroxidation to some ex¬tent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes.