Immunohistoochemical evaluation of GATA-3, pAKT and Ki-67 in triple negative breast carcinoma

• Main Authors: Gopi Aryal (Author), Sameer Chhetri Aryal (Author), Yurie Soejima (Author), Victoria Sheckler (Author), Yoshinobu Eishi (Author), Motoji Sawabe (Author)
• Format: Book
• Published: Association of Clinical Pathologists of Nepal, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p><strong>Background:</strong> Triple-negative breast cancers lack expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor -2. These tumors have been known to be clinically aggressive. We evaluate GATA-3, <em>pAKT </em>and Ki-67 expression in 35 triple negative breast carcinomas.</p><p><strong>Materials and Methods:</strong> A total of 35 triple negative breast carcinomas were included in this study. The histological subtyping was done according to Japanese guidelines for breast cancer.</p><p><strong>Results: </strong>GATA-3 was positive in 60% (21/35) of tumors. High GATA-3 expression was observed in ductal carcinoma in situ.  pAKT expression was demonstrated in 85.7 % (30/35) of TNBCs. The levels of expression of GATA-3 and pAKT showed no significant association with nuclear grading. (P=0.761 and P=0.487, respectively). Ki-67 labeling index was positively correlated with nuclear grading (p<0.001).</p><p><strong>Conclusion: </strong>GATA-3 expression has no relation with ER and PR expression and pAKT and GATA-3 are strongly expressed in TNBCs. </p>

Item Description

2091-0797
2091-0908
10.3126/jpn.v7i2.18037