Pharmacokinetics and bioequivalence of sunitinib and Sutent® in Chinese healthy subjects: an open-label, randomized, crossover study

• Main Authors: Yanli Wang (Author), Qiaohuan Deng (Author), Zhenyue Gao (Author), Guangwen Liu (Author), Zhengjie Su (Author), Yicheng Zhao (Author), Lixiu Zhang (Author), Haimiao Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The purpose of this study was to examine the pharmacokinetics (PK), bioequivalence and safety of generic sunitinib and its original product Sutent® in healthy Chinese subjects through a phase-I clinical trial.Methods: The study selected two groups of 24 healthy Chinese subjects in a 1:1 rat...