Multiple rapid-responsive probes for hypochlorite detection based on dioxetane luminophore derivatives
In recent years, various methods for detecting exogenous and endogenous hypochlorite have been studied, considering its essential role as a biomolecule. However, the existing technologies still pose obstacles such as their invasiveness, high costs, and complicated operation. In the current study, we...
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Elsevier,
2022-06-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_9dd7de92e4cb4daaa1ae2eb722a20e7a | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yingai Sun |e author |
| 700 | 1 | 0 | |a Yuqi Gao |e author |
| 700 | 1 | 0 | |a Chunchao Tang |e author |
| 700 | 1 | 0 | |a Gaopan Dong |e author |
| 700 | 1 | 0 | |a Pei Zhao |e author |
| 700 | 1 | 0 | |a Dunquan Peng |e author |
| 700 | 1 | 0 | |a Tiantian Wang |e author |
| 700 | 1 | 0 | |a Lupei Du |e author |
| 700 | 1 | 0 | |a Minyong Li |e author |
| 245 | 0 | 0 | |a Multiple rapid-responsive probes for hypochlorite detection based on dioxetane luminophore derivatives |
| 260 | |b Elsevier, |c 2022-06-01T00:00:00Z. | ||
| 500 | |a 2095-1779 | ||
| 500 | |a 10.1016/j.jpha.2021.10.001 | ||
| 520 | |a In recent years, various methods for detecting exogenous and endogenous hypochlorite have been studied, considering its essential role as a biomolecule. However, the existing technologies still pose obstacles such as their invasiveness, high costs, and complicated operation. In the current study, we developed a glow-type chemiluminescent probe, hypochlorite chemiluminescence probe (HCCL)-1, based on the scaffold of Schaap's 1,2-dioxetane luminophores. To better explore the physiological and pathological functions of hypochlorite, we modified the luminophore scaffold of HCCL-1 to develop several probes, including HCCL-2, HCCL-3, and HCCL-4, which amplify the response signal of hypochlorite. By comparing the luminescent intensities of the four probes using the IVIS® system, we determined that HCCL-2 with a limit of detection of 0.166 μM has enhanced sensitivity and selectivity for tracking hypochlorite both in vitro and in vivo. | ||
| 546 | |a EN | ||
| 690 | |a Glow-type | ||
| 690 | |a Chemiluminescent probe | ||
| 690 | |a 1,2-Dioxetane | ||
| 690 | |a Hypochlorite | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmaceutical Analysis, Vol 12, Iss 3, Pp 446-452 (2022) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2095177921001155 | |
| 787 | 0 | |n https://doaj.org/toc/2095-1779 | |
| 856 | 4 | 1 | |u https://doaj.org/article/9dd7de92e4cb4daaa1ae2eb722a20e7a |z Connect to this object online. |