The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b

• Main Authors: Yue-Zhi Lee (Author), Hsing-Yu Hsu (Author), Cheng-Wei Yang (Author), Yi-Ling Lin (Author), Sui-Yuan Chang (Author), Ruey-Bing Yang (Author), Jian-Jong Liang (Author), Tai-Ling Chao (Author), Chun-Che Liao (Author), Han-Chieh Kao (Author), Jang-Yang Chang (Author), Huey-Kang Sytwu (Author), Chiung-Tong Chen (Author), Shiow-Ju Lee (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ciclesonide is an inhaled corticosteroid used to treat asthma and has been repurposed as a treatment for mildly ill COVID-19 patients, but its precise mechanism of action is unclear. Herein, we report that ciclesonide blocks the coronavirus-induced production of the cytokines IL-6, IL-8, and MCP-1 b...