A Cyclic Peptide Epitope of an Under-Explored VEGF-B Loop 1 Demonstrated In Vivo Anti-Angiogenic and Anti-Tumor Activities

• Main Authors: Lei Wang (Author), Meng Xu (Author), Haofeng Hu (Author), Lun Zhang (Author), Fei Ye (Author), Jia Jin (Author), Hongming Fang (Author), Jian Chen (Author), Guiqian Chen (Author), Sylvain Broussy (Author), Michel Vidal (Author), Zhengbing Lv (Author), Wang-Qing Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pathological angiogenesis is mainly initiated by the binding of abnormal expressed vascular endothelial growth factors (VEGFs) to their receptors (VEGFRs). Blocking the VEGF/VEGFR interaction is a clinically proven treatment in cancer. Our previous work by epitope scan had identified cyclic peptides...