A Polymorphism in the Gene Encoding the Insulin Receptor Binding Protein ENPP-1 Is Associated with Decreased Glomerular Filtration Rate in an Under-Investigated Indigenous African Population

• Autors principals: Eleanor M. Cave (Autor), Katherine L. Prigge (Autor), Nigel J. Crowther (Autor), Jaya A. George (Autor), Carolyn J. Padoa (Autor)
• Format: Llibre
• Publicat: Karger Publishers, 2020-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Introduction: The C allele of the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP-1) rs1044498 polymorphism has previously been associated with increased binding of ENPP-1 to the insulin receptor (IR), resulting in decreased IR signalling and enhanced insulin resistance. It has also been as...