A Comparison of the 𝜶2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain

• Main Authors: Sarah Nickolls (Author), Hannah Mace (Author), Rebecca Fish (Author), Michelle Edye (Author), Rachel Gurrell (Author), Magnus Ivarsson (Author), Tom Pitcher (Author), Sachi Tanimoto-Mori (Author), Denise Richardson (Author), Catherine Sweatman (Author), Janet Nicholson (Author), Cameron Ward (Author), John Jinks (Author), Christine Bell (Author), Kimberly Young (Author), Huw Rees (Author), Andrew Moss (Author), Ross Kinloch (Author), Gordon McMurray (Author)
• Format: Book
• Published: Hindawi Limited, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

GABAA receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. However, this approach is prone to a range of side effects including sedation, cognitive...