Anticholinesterase activity of β-carboline-1,3,5-triazine hybrids

• Auteurs principaux: Paula Baréa (Auteur), Valéria Aquilino Barbosa (Auteur), Diego Alberto dos Santos Yamazaki (Auteur), Carla Maria Beraldi Gomes (Auteur), Claudio R. Novello (Auteur), Willian Ferreira da Costa (Auteur), Gisele de Freitas Gauze (Auteur), Maria Helena Sarragiotto (Auteur)
• Format: Livre
• Publié: Universidade de São Paulo, 2022-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract The β-carboline-1,3,5-triazine hydrochlorides 8-13 were evaluated in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The analysed compounds were selective to BuChE, with IC50 values in the range from 1.0-18.8 µM being obtained. The N-{2-[(4,6-dihydrazinyl-1,3,5-...