Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity.

• Main Authors: Joana Faria (Author), Inês Loureiro (Author), Nuno Santarém (Author), Sandra Macedo-Ribeiro (Author), Joana Tavares (Author), Anabela Cordeiro- (Author)
• Format: Bog
• Udgivet: Public Library of Science (PLoS), 2016-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

A growing interest in asparagine (Asn) metabolism has currently been observed in cancer and infection fields. Asparagine synthetase (AS) is responsible for the conversion of aspartate into Asn in an ATP-dependent manner, using ammonia or glutamine as a nitrogen source. There are two structurally dis...