Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors
TRYPANOSOMA cruzi is the etiologic agent of Chagas' disease, a parasitic disease of enormous importance in Latin America. Herein we review the studies that revealed the receptors from innate immunity that are involved in the recognition of this protozoan parasite. We showed that the recognition...
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| Main Authors: | , |
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| Format: | Book |
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Hindawi Limited,
2004-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | TRYPANOSOMA cruzi is the etiologic agent of Chagas' disease, a parasitic disease of enormous importance in Latin America. Herein we review the studies that revealed the receptors from innate immunity that are involved in the recognition of this protozoan parasite. We showed that the recognition of T. cruzi and its components occurs through Toll-like receptors (TLR) 2/CD14. Further, we showed in vivo the importance of the myeloid differentiation factor (MyD88), an adapter protein essential for the function of TLRs, in determining the parasitemia and mortality rate of mice infected with T. cruzi. We also discuss the implications of these findings in the pathophysiology of Chagas' disease. |
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| Item Description: | 0962-9351 1466-1861 10.1080/09511920410001713565 |