Novel mutations of PKD genes in Chinese patients suffering from autosomal dominant polycystic kidney disease and seeking assisted reproduction

• Main Authors: Wen-Bin He (Author), Wen-Juan Xiao (Author), Yue-Qiu Tan (Author), Xiao-Meng Zhao (Author), Wen Li (Author), Qian-Jun Zhang (Author), Chang-Gao Zhong (Author), Xiu-Rong Li (Author), Liang Hu (Author), Guang-Xiu Lu (Author), Ge Lin (Author), Juan Du (Author)
• Format: Book
• Published: BMC, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Autosomal dominant polycystic kidney disease (ADPKD), the commonest inherited kidney disease, is generally caused by heterozygous mutations in PKD1, PKD2, or GANAB (PKD3). Methods We performed mutational analyses of PKD genes to identify causative mutations. A set of 90 unrelated...